Methoxychlor Hepatotoxicity and Trials of Camel Milk Restoration
Eman E. Elsharkawy *
Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Assuit University, Egypt.
Eman M. Shaker
Department of Food Hygiene, Faculty of Veterinary Medicine, Sohag University, Egypt.
Neveen A. El-Nisr
Animal Health Research Institute, Assuit, Egypt.
Nahed, M. Wahba
Animal Health Research Institute, Assuit, Egypt.
*Author to whom correspondence should be addressed.
Abstract
The present study was carried out to investigate the restoration effect of camel's milk against methoxychlor induced liver toxicity. The unique characters of camel’s milk make it used extensively in the field of medicine as anti-microbial, anti-diabetic and as a hepatoprotective agent. Methoxychlor is an environmental contaminant, which is widely used as a pesticide in many countries, has been shown to induce hepatotoxicity in rat. MXC caused a significant increase in serum transaminases (AST and ALT), and alkaline phosphatase, while MXC induced a significant reduction in total protein and albumin levels. MXC significantly inhibited lipid peroxidation and markedly enhanced glutathione in liver homogenate. Pathological damages as degeneration and coagulative necrosis of the hepatocytes were established in liver. Newly formed bile ducteules denotes neoplastic changes in the portal tract with abnormal mitotic pattern were associated with the long term exposure. The present study concluded that camel milk treatment may play a protective role against methoxychlor -induced liver damage in rats.
Keywords: Coheritability in Lentil, Hepatotoxicity, Lentil breeding, methoxychlor, AST, ALT, oxidative stress, camel milk.